Extended Interneuronal Network of the Dentate Gyrus

Extended Interneuronal Network of the Dentate Gyrus

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Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes grahams c+ eczema & dermatitis cream extend beyond strict anatomical boundaries.Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells.These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the jordan 12 nubuck canonical interneuronal network.